Collagen™ injection is a popular non-surgical cosmetic procedure that uses a natural substance derived from purified bovine collagen and is used to replace the collagen the skin loses over time. Collagen™, patented by the Collagen™ Corporation under the trade names Zyderm and Zyplast, received approval from the Food and Drug Administration in 1981 and since then been one of the top ten procedures administered to patients. For those of you looking for a quick and painless procedure to smooth out facial lines and wrinkles, Collagen™ injection is a good alternative to plastic surgery. The use of Collagen™ requires skin testing and therefore a consultation appointment is necessary prior to treatment with Collagen™.